|
KMID : 0388420000100010119
|
|
Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.119 ~ p.126
|
|
|
A Study of Correlation with Bone Turnover Markers and Bone Mineral Density in Women for Health Examination
|
|
Choi Young-Sook
Cho Dong-Young
|
|
|
Abstract
|
|
|
Background: Osteoporosis leads to a reduction in absolute bone volume and results when bone loss is sufficient to cause increased risk of fracture.
The combination of bone turnover markers ´and bone mineral density(BMD) evaluation is helpful in identifying patients at risk of osteoporosis, especially perimenopausal women, who should be offered early preventive treatment before appreciable bone loss occurs.
Methods: The authors measured serum osteocalcin levels as a bone formation marker, urinary N-telopeptide of type 1 collagen(NTx) levels as a bone resorption marker, and checked lumbar spine BMD in 50 women for health examination. Osteocalcin, NTx and BMD levels were analysed according to age. Bone turnover, markers were compared with BMD. These bone turnover markers were compared with each other.
Results: Osteocalcin and NTx levels correlated significantly with each other. These biochemical bone markers were higher in women after 49 years than before 48 years. These markers decreased after seventh decades, but these values showed more increased levels than before 48 years. BMD decreased with age. Biochemical bone markers and BMD showed negative correlations.
Conclusion: Osteocalcin and NTx levels show significant difference between premenopausal and postmenopausal women, Bone resorption marker is more or less responsive to changes in bone metabolism than bone formation marker. The authors suggest a woman who has normal bone mass but is a fast-loser with increased bone resorption may be at greater risk for subsequent osteoporosis than a woman who has a lower bone mass but who is a slow-loser.
|
|
|
KEYWORD
|
|
|
bone turnover marker, bone mineral density, osteocalcin, N-telopeptide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|